Journal article

Comprehensive Synthesis of Substrates, Intermediates, and Products of the Sulfoglycolytic Embden-Meyerhoff-Parnas Pathway

Palika Abayakoon, Ruwan Epa, Marija Petricevic, Christopher Bengt, Janice W-Y Mui, Phillip L van der Peet, Yunyang Zhang, James P Lingford, Jonathan M White, Ethan D Goddard-Borger, Spencer J Williams

JOURNAL OF ORGANIC CHEMISTRY | AMER CHEMICAL SOC | Published : 2019

Abstract

Sulfoglycolysis is a metabolic pathway dedicated to the catabolism of the sulfosugar sulfoquinovose (SQ) into smaller organosulfur fragments. An estimated 10 billion tonnes of SQ fluxes through sulfoglycolysis pathways each year, making it a significant aspect of the biogeochemical sulfur cycle. Delineating the molecular details of sulfoglycolysis requires authentic samples of the various metabolites in these pathways. To this end, we have established chemical and chemoenzymatic methods for the synthesis of the key organosulfur metabolites sulfoquinovosylglycerol, SQ (also in 13C6-labeled form), sulfofructose, sulfofructose-1-phosphate, sulfolactaldehyde, and 2,3-dihydroxypropanesulfonate, a..

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Grants

Awarded by Australian Research Council


Awarded by National Health and Medical Research Council


Funding Acknowledgements

We thank the Australian Research Council (DP180101957) and the National Health and Medical Research Council (GNT1139549) for financial support, as well as the Australian Synchrotron for beamtime via the Collaborative Access Program (proposal number 13618b).