CD4( ) T help promotes influenza virus-specific CD8( ) T cell memory by limiting metabolic dysfunction
Jolie G Cullen, Hayley A McQuilten, Kylie M Quinn, Moshe Olshansky, Brendan E Russ, Alison Morey, Sanna Wei, Julia E Prier, Nicole L La Gruta, Peter C Doherty, Stephen J Turner
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | NATL ACAD SCIENCES | Published : 2019
There is continued interest in developing novel vaccine strategies that induce establish optimal CD8+ cytotoxic T lymphocyte (CTL) memory for pathogens like the influenza A viruses (IAVs), where the recall of IAV-specific T cell immunity is able to protect against serologically distinct IAV infection. While it is well established that CD4+ T cell help is required for optimal CTL responses and the establishment of memory, when and how CD4+ T cell help contributes to determining the ideal memory phenotype remains unclear. We assessed the quality of IAV-specific CD8+ T cell memory established in the presence or absence of a concurrent CD4+ T cell response. We demonstrate that CD4+ T cell help a..View full abstract
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Awarded by National Health and Medical Research Council of Australia
This work was supported by National Health and Medical Research Council of Australia Program Grant 5671222 (to S.J.T. and P.C.D.) and Project Grant APP1003131 (to S.J.T.). N.L.L.G. is supported by an Australian Research Council Future Fellowship. S.J.T. is supported by a National Health and Medical Research Council Principal Research fellowship.