Relationships between adrenarcheal hormones, hippocampal volumes and depressive symptoms in children
Rachel Ellis, Anna Fernandes, Julian G Simmons, Lisa Mundy, George Patton, Nicholas B Allen, Sarah Whittle
PSYCHONEUROENDOCRINOLOGY | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2019
Early timing of puberty (i.e., advanced pubertal maturation relative to same-age peers) has been associated with depressive symptoms during adolescence. To date, research on this relationship has focused on gonadarche, the second phase of puberty, while less is known about the first phase of puberty, adrenarche. Increasing evidence suggests that androgens that rise during adrenarche, most notably dehyrdoepiandrosterone (DHEA) and testosterone, may be involved both in the development of the hippocampus, and risk for depression. The current study investigated whether hippocampal volumes mediated the relationship between adrenarcheal timing (based on relative levels of adrenarcheal hormones) an..View full abstract
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Awarded by Australian Research Council (ARC)
Awarded by National Health and Medical Research Council (NHMRC)
The authors declare no competing financial interests. This work was supported by the Australian Research Council (ARC; DP120101402), and the National Health and Medical Research Council (NHMRC; Career Development Fellowship 1125504 to SW).