Journal article
Sulphadoxine-pyrimethamine plus azithromycin may improve birth outcomes through impacts on inflammation and placental angiogenesis independent of malarial infection
HW Unger, AP Hansa, C Buffet, W Hasang, A Teo, L Randall, M Ome-Kaius, S Karl, AA Anuan, JG Beeson, I Mueller, SJ Stock, SJ Rogerson
Scientific Reports | NATURE PORTFOLIO | Published : 2019
Abstract
Intermittent preventive treatment with sulphadoxine-pyrimethamine (SP) and SP plus azithromycin (SPAZ) reduces low birthweight (<2,500 g) in women without malarial and reproductive tract infections. This study investigates the impact of SPAZ on associations between plasma biomarkers of inflammation and angiogenesis and adverse pregnancy outcomes in 2,012 Papua New Guinean women. Concentrations of C-reactive protein (CRP), α-1-acid glycoprotein (AGP), soluble endoglin (sEng), soluble fms-like tyrosine kinase-1 (sFlt-1) and placental growth factor (PlGF) were measured at enrolment and delivery in a trial comparing SPAZ to SP plus chloroquine (SPCQ). At antenatal enrolment higher CRP (adjusted ..
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Grants
Awarded by European Commission
Funding Acknowledgements
We would like to thank all participants, their families and children; Dr. Alex Umbers, Dr. Leanne Robinson, and Dr. Regina Wangnapi; and all staff at the PNG Institute of Medical Research, without whom the study would not have been possible. The work was funded by a Thrasher Early Career Award (12934 to H.W.U); the Malaria in Pregnancy Consortium, through a grant from the Bill & Melinda Gates Foundation (46099 to S.J.R); Pregvax Consortium, through a grant from the European Union's Seventh Framework Programme (FP7-2007-HEALTH, PREGVAX 201588 to S.J.R and I.M.) and the Spanish Government (EUROSALUD 2008 Programme); a Pfizer Inc Investigator-Initiated Research grant (WS394663 to S.J.R); an National Health and Medical Research (NHMRC) Program Grant (1092789 to S.J.R, J.G.B, I.M.); NHMRC Fellowships (1077636 to J.G.B, 1043345 to I. M., GNT1141441 to S.K.); a Wellcome Trust Clinical Career Development Fellowship (209560/Z/17/Z to S.J.S); and Tommy's Charity (to S.J.S). The funding bodies had no role in study design, and the collection, analysis and interpretation of the data.