Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes

JC Barrett; DG Clayton; P Concannon; B Akolkar; JD Cooper; HA Erlich; C Julier; G Morahan; J Nerup; C Nierras; V Plagnol; F Pociot; H Schuilenburg; DJ Smyth; H Stevens; JA Todd; NM Walker; SS Rich; T Baskerville; N Bautista; E Bhatia; V Bhatia; K Bin Hasan; F Bonnici; T Brodnicki; F Cameron; K Chaichanwatanakul; PT Cheung; P Colman; A Cotterill; J Couper; R Cutfield; T Davis; P Dixon; K Donaghue; K Dowling; P Drury; S Dye; S Gellert; R Abdul Ghani; R Greer; X Han; L Harrison; N Homatopoulos; L Ji; T Jones; LK Yin; NA Kamaruddin; U Kanga; A Kanungo; G Kaur; B Kek; S Knowles; J Krebs; N Kumar; YJ Lee; X Li; S Liktimaskul; M Lloyd; A Loth; A Louey; N Mehra; T Merriman; L Min; R Moses; G Mraz; R Murphy; I Nicholson; A Panelo; P Poh; G Price; N Ratnam; C Sanjeevi; S Sedimbi; S Shen; GS Ying; B Tait; N Tandon; A Thomas; M Varney; P Weerakulwattana; J Willis; L Albret; F Ampudia-Blasco; J Argente; G Babadjanova; K Badenhoop; T Battelino; G Beilhack; R Bergholdt; P Bingley; B Boehm; J Bolidson; C Brorsson; J Carlson; L Castano; K Chandler; O Cinek; E Cipponeri; R Corripio

Journal article

Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes

JC Barrett, DG Clayton, P Concannon, B Akolkar, JD Cooper, HA Erlich, C Julier, G Morahan, J Nerup, C Nierras, V Plagnol, F Pociot, H Schuilenburg, DJ Smyth, H Stevens, JA Todd, NM Walker, SS Rich, T Baskerville, N Bautista Show all

Nature Genetics | NATURE PUBLISHING GROUP | Published : 2009

DOI: 10.1038/ng.381

Abstract

Type 1 diabetes (T1D) is a common autoimmune disorder that arises from the action of multiple genetic and environmental risk factors. We report the findings of a genome-wide association study of T1D, combined in a meta-analysis with two previously published studies. The total sample set included 7,514 cases and 9,045 reference samples. Forty-one distinct genomic locations provided evidence for association with T1D in the meta-analysis (P 10 6). After excluding previously reported associations, we further tested 27 regions in an independent set of 4,267 cases, 4,463 controls and 2,319 affected sib-pair (ASP) families. Of these, 18 regions were replicated (P 0.01; overall P 5 × 10 8) and 4 add..

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