Peripheral biomarkers in glioblastoma patients-is it all just HOTAIR?

Abstract

Glioblastoma multiforme is the most aggressive form of brain cancer. The standard of care treatment for newly diagnosed patients with glioblastoma is tumour de-bulking by surgery, followed combination therapy consisting of radiation and temozolomide chemotherapy (1). The tumour invariably recur, often in the same area or adjacent to as the original surgical-resected tumor (2,3).