Journal article

Thoracic sympathetic chain stimulation modulates and entrains the respiratory pattern

RR Dhingra, G Kola, SJ Lewis, M Dutschmann

AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL | ELSEVIER SCIENCE BV | Published : 2019

Abstract

Stimulation of thoracic sympathetic chain (TSC) afferents has been shown to slow the respiratory rhythm in dogs, monkeys and humans. However, sparse information exists about the physiological role of TSC afferents in modulating respiration or the central pathways of these afferents. Here, we sought to investigate whether the perfused preparation of juvenile rats is a suitable experimental model to study the role of TSC-afferents in the modulation of respiration. We show that tonic (30s) TSC stimulation initially triggered either prolonged post-inspiratory vagal nerve discharge, or when the stimulus onset occurred in the second half of expiration, TSC stimulation also modulated late-expirator..

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