Thoracic sympathetic chain stimulation modulates and entrains the respiratory pattern
RR Dhingra, G Kola, SJ Lewis, M Dutschmann
AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL | ELSEVIER SCIENCE BV | Published : 2019
Stimulation of thoracic sympathetic chain (TSC) afferents has been shown to slow the respiratory rhythm in dogs, monkeys and humans. However, sparse information exists about the physiological role of TSC afferents in modulating respiration or the central pathways of these afferents. Here, we sought to investigate whether the perfused preparation of juvenile rats is a suitable experimental model to study the role of TSC-afferents in the modulation of respiration. We show that tonic (30s) TSC stimulation initially triggered either prolonged post-inspiratory vagal nerve discharge, or when the stimulus onset occurred in the second half of expiration, TSC stimulation also modulated late-expirator..View full abstract
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Awarded by National Institutes of Health
Awarded by Australian Research Council
This work was supported by the National Institutes of Health [NIH 1OT1TR001779-01] and the Australian Research Council [DP170104861].