Hepatitis B virus-like particles expressing Plasmodium falciparum epitopes induce complement-fixing antibodies against the circumsporozoite protein
Natalie J Kingston, Liriye Kurtovic, Renae Walsh, Carina Joe, George Lovrecz, Stephen Locarnini, James G Beeson, Hans J Netter
VACCINE | ELSEVIER SCI LTD | Published : 2019
The repetitive structure of compact virus-like particles (VLPs) provides high density displays of antigenic sequences, which trigger key parts of the immune system. The hepatitis B virus (HBV) and human papilloma virus (HPV) vaccines exploit the assembly competence of structural proteins, which are the effective immunogenic components of the prophylactic HBV and HPV vaccines, respectively. To optimize vaccine designs and to promote immune responses against protective epitopes, the "Asp-Ala-Asp-Pro" (NANP)-repeat from the Plasmodium falciparum circumsporozoite protein (CSP) was expressed within the exposed, main antigenic site of the small HBV envelope protein (HBsAgS); this differs from the ..View full abstract
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Awarded by National Health and Medical Research Council (NHMRC) Australia
This study was partly supported by the National Health and Medical Research Council (NHMRC) Australia, Research Project Grant APP1127538 awarded to SL, RW and HJN, Senior Research Fellowship to JGB (1077636) and Program Grant to JGB (1092789), and Australian Government Research Training Program Scholarship awarded to LK. The Burnet Institute was supported by the NHMRC Independent Research Institutes Infrastructure Support Scheme and an Operational Infrastructure Grant from the State Government of Victoria.