Early-Life Formation of the Microbial and Immunological Environment of the Human Airways.
Céline Pattaroni, Martin L Watzenboeck, Sabrina Schneidegger, Silas Kieser, Nicholas C Wong, Eric Bernasconi, Julie Pernot, Louis Mercier, Sylvia Knapp, Laurent P Nicod, Colin P Marsland, Matthias Roth-Kleiner, Benjamin J Marsland
Cell Host & Microbe | Published : 2018
Crosstalk between immune cells and the microbiota in mucosal tissues can set an individual on a trajectory toward health or disease. Little is known about these early-life events in the human respiratory tract. We examined bacterial colonization and immune system maturation in the lower airways over the first year of life. The lower respiratory tract microbiota forms within the first 2 postnatal months. Within the first weeks, three microbial profiles are evident, broadly distinguished as dysbiotic or diverse, and representing different microbial virulence potentials, including proteolysis of immunoglobulin A (IgA) that is critical for mucosal defense. Delivery mode determines microbiota con..View full abstract