Journal article

Analyses of pig genomes provide insight into porcine demography and evolution.

Martien AM Groenen, Alan L Archibald, Hirohide Uenishi, Christopher K Tuggle, Yasuhiro Takeuchi, Max F Rothschild, Claire Rogel-Gaillard, Chankyu Park, Denis Milan, Hendrik-Jan Megens, Shengting Li, Denis M Larkin, Heebal Kim, Laurent AF Frantz, Mario Caccamo, Hyeonju Ahn, Bronwen L Aken, Anna Anselmo, Christian Anthon, Loretta Auvil Show all

Nature | Published : 2012


For 10,000 years pigs and humans have shared a close and complex relationship. From domestication to modern breeding practices, humans have shaped the genomes of domestic pigs. Here we present the assembly and analysis of the genome sequence of a female domestic Duroc pig (Sus scrofa) and a comparison with the genomes of wild and domestic pigs from Europe and Asia. Wild pigs emerged in South East Asia and subsequently spread across Eurasia. Our results reveal a deep phylogenetic split between European and Asian wild boars ∼1 million years ago, and a selective sweep analysis indicates selection on genes involved in RNA processing and regulation. Genes associated with immune response and olfac..

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Awarded by Biotechnology and Biological Sciences Research Council

Awarded by NIAID NIH HHS

Awarded by NCRR NIH HHS

Awarded by NIDA NIH HHS

Awarded by European Research Council

Awarded by Wellcome Trust

Awarded by NLM NIH HHS

Awarded by NHGRI NIH HHS

Awarded by Chief Scientist Office

Awarded by Medical Research Council