Journal article
Memory inflation following adenoviral vaccination depends on IL-21
CL Gordon, CL Hutchings, AJ Highton, JM Colston, NM Provine, P Klenerman
Vaccine | ELSEVIER SCI LTD | Published : 2018
Abstract
Cytomegalovirus (CMV) and non-replicating adenoviral vectors can induce expanded, sustained effector-memory CD8+ T-cell responses, termed “memory inflation”. During murine CMV (MCMV) infection, CD4+ Tcells maintain inflationary virus-specific CD8+ T-cell responses via IL-2 but not IL-21. Adenovirus vector vaccination can induce phenotypically, functionally and transcriptionally similar inflationary responses, but it is not known how IL-21 influences the inflating memory response to adenoviral vaccination. Here, we show that IL-21 is an absolute requirement for induction and maintenance of vaccine-derived inflationary CD8+ T-cell responses. These data indicate that the induction pathway of in..
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Awarded by National Institute on Handicapped Research
Funding Acknowledgements
This work was supported by a Wellcome Trust fellowship (WTO91663MA and 109965MA) to P.K., NIH (U19AI 082630), the Oxford Martin School, the Oxford University Returning Carers Fund (C.H.), Endeavour Postgraduate Scholarship (C.L.G.), and Oxford-UCB Postdoctoral Fellowship (N.M.P.). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. We acknowledge the NIH Tetramer Core Facility (HHSN272201300006C) for provision of MHC class I monomers. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. The authors have no competing financial interests.