Journal article
Genome-wide association meta-analysis of functional outcome after ischemic stroke
M Söderholm, A Pedersen, E Lorentzen, TM Stanne, S Bevan, M Olsson, JW Cole, I Fernandez-Cadenas, GJ Hankey, J Jimenez-Conde, K Jood, JM Lee, R Lemmens, C Levi, BD Mitchell, B Norrving, K Rannikmäe, NS Rost, J Rosand, PM Rothwell Show all
Neurology | LIPPINCOTT WILLIAMS & WILKINS | Published : 2019
Open access
Abstract
ObjectiveTo discover common genetic variants associated with poststroke outcomes using a genome-wide association (GWA) study.MethodsThe study comprised 6,165 patients with ischemic stroke from 12 studies in Europe, the United States, and Australia included in the GISCOME (Genetics of Ischaemic Stroke Functional Outcome) network. The primary outcome was modified Rankin Scale score after 60 to 190 days, evaluated as 2 dichotomous variables (0-2 vs 3-6 and 0-1 vs 2-6) and subsequently as an ordinal variable. GWA analyses were performed in each study independently and results were meta-analyzed. Analyses were adjusted for age, sex, stroke severity (baseline NIH Stroke Scale score), and ancestry...
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Awarded by Instituto de Salud Carlos III
Funding Acknowledgements
The Stroke Genetics Network (SiGN) study was funded by a cooperative agreement grant from the US National Institute of Neurological Disorders and Stroke (NINDS), NIH (U01 NS069208 and R01 NS100178). SAHLSIS was supported by the Swedish Heart and Lung Foundation (HLF-20160316), the Swedish Research Council (K2014-64X-14605-12-5), the Swedish Stroke Association, the Swedish state (under the "Avtal om Lakarutbildning och Medicinsk Forskning, ALF") (ALFGBG-720081). Australian Stroke Genetics Collaboration study was supported by the National Health and Medical Research Council, Australia. Stroke Pharmacogenomics and Genetics group was supported by Invictus plus network, Generation project, and Miguel Servet programme from Instituto de Salud Carlos III, GODs project and Epigenesis project from Marato de TV3 Foundation and Agaur from Generalitat de Catalunya Government. Arne Lindgren was supported by the Swedish Heart and Lung Foundation, Region Skane, Skane University Hospital, the Freemasons Lodge of Instruction EOS in Lund, Lund University, the Foundation of Fars & Frosta-one of Sparbanken Skane's ownership Foundations, and the Swedish Stroke Association. Martin Soderholm was supported by grants from the Swedish Stroke Association, the Foundation of Fars & Frosta-one of Sparbanken Skane's ownership Foundations, and the Swedish government (under the "Avtal om Lakarutbildning och Medicinsk Forskning, ALF"). Annie Pedersen was supported by grants from the Swedish government (under the "Avtal om Lakarutbildning och Medicinsk Forskning, ALF") and the Gothenburg Foundation for Neurological Research. Natalia Rost was in part supported by NIH-NINDS (R01NS086905 and R01NS082285). Daniel Strbian was supported by the Finnish Subsidiary Governmental Fund (VTR). The authors thank NINDS for funding the genotyping of patients included in the SiGN study (U01 NS069208 and R01 NS100178) and Solveig Gretarsdottir for genotyping a subsample of the SAHLSIS cohort.