Protein Adsorption and Coordination-Based End-Tethering of Functional Polymers on Metal-Phenolic Network Films

Blaise L Tardy; Joseph J Richardson; Vichida Nithipipat; Kristian Kempe; Junling Guo; Kwun Lun Cho; Md Arifur Rahim; Hirotaka Ejima; Frank Caruso

Journal article

Protein Adsorption and Coordination-Based End-Tethering of Functional Polymers on Metal-Phenolic Network Films

Blaise L Tardy, Joseph J Richardson, Vichida Nithipipat, Kristian Kempe, Junling Guo, Kwun Lun Cho, Md Arifur Rahim, Hirotaka Ejima, Frank Caruso

BIOMACROMOLECULES | AMER CHEMICAL SOC | Published : 2019

DOI: 10.1021/acs.biomac.9b00006

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Abstract

Metal-phenolic network (MPN) coatings have generated increasing interest owing to their biologically inspired nature, facile fabrication, and near-universal adherence, especially for biomedical applications. However, a key issue in biomedicine is protein fouling, and the adsorption of proteins on tannic acid-based MPNs remains to be comprehensively studied. Herein, we investigate the interaction of specific biomedically relevant proteins in solution (e.g., bovine serum albumin (BSA), immunoglobulin G (IgG), fibrinogen) and complex biological media (serum) using layer-by-layer-assembled tannic acid/FeIII MPN films. When FeIII was the outermost layer, galloyl-modified poly(2-ethyl-2-oxazoline)..

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University of Melbourne Researchers

Frank Caruso Author Chemical Engineering

Jj Richardson Author Chemical Engineering

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Grants

Awarded by Australian Research Council (ARC) Centre of Excellence in Convergent Bio-Nano Science and Technology

Awarded by ARC Discovery Project

Awarded by National Health and Medical Research Council Senior Principal Research Fellowship

Funding Acknowledgements

This research was conducted and funded by the Australian Research Council (ARC) Centre of Excellence in Convergent Bio-Nano Science and Technology (Project No. CE140100036) and an ARC Discovery Project (DP170103331). F.C. acknowledges the award of a National Health and Medical Research Council Senior Principal Research Fellowship (APP1135806). K.K. acknowledges the Alexander von Humboldt Foundation for a Feodor Lynen Research Fellowship. This work was performed in part at the Materials Characterisation and Fabrication Platform at The University of Melbourne and the Victorian Node of the Australian National Fabrication Facility.