Journal article

The impact of fasting on resting state brain networks in mice

Tomokazu Tsurugizawa, Boucif Djemai, Andrew Zalesky

SCIENTIFIC REPORTS | NATURE RESEARCH | Published : 2019

Abstract

Fasting is known to influence learning and memory in mice and alter the neural networks that subserve these cognitive functions. We used high-resolution functional MRI to study the impact of fasting on resting-state functional connectivity in mice following 12 h of fasting. The cortex and subcortex were parcellated into 52 subregions and functional connectivity was measured between each pair of subregions in groups of fasted and non-fasted mice. Functional connectivity was globally increased in the fasted group compared to the non-fasted group, with the most significant increases evident between the hippocampus (bilateral), retrosplenial cortex (left), visual cortex (left) and auditory corte..

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University of Melbourne Researchers