Journal article

Inflammation and hearing status in mid-childhood and mid-life: a population-based cross-sectional study

Jing Wang, Valerie Sung, Peter Carew, Richard S Liu, David Burgner, Melissa Wake

International Journal of Epidemiology | OXFORD UNIV PRESS | Published : 2019

Abstract

BACKGROUND: Lifelong inflammation - known to be associated with many non-communicable diseases - has not been thoroughly investigated in hearing. We aimed to determine if glycoprotein A (GlycA), a novel biomarker of chronic inflammation, is associated with hearing acuity in mid-childhood and mid-life. METHODS: Population-based cross-sectional study within the Longitudinal Study of Australian Children with plasma GlycA and audiometry data (1169 children and 1316 parents). We calculated high Fletcher Index (mean threshold across 1, 2 and 4 kHz), defining hearing loss as threshold >15 decibel hearing level (dB HL) (better ear). Linear/logistic regression quantified associations of GlycA with he..

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Grants

Awarded by Australian National Health and Medical Research Council (NHMRC)


Awarded by Royal Children's Hospital Foundation


Awarded by National Heart Foundation of Australia


Awarded by Financial Markets Foundation for Children


Awarded by NHMRC


Funding Acknowledgements

This work was supported by the Australian National Health and Medical Research Council (NHMRC) Project Grants [1041352, 1109355]; The Royal Children's Hospital Foundation [2014-241]; the Murdoch Children's Research Institute; The University of Melbourne; the National Heart Foundation of Australia [100660]; Financial Markets Foundation for Children [2014-055, 2016-310]; the Victorian Deaf Education Institute; and the Victorian Government's Operational Infrastructure Support Program. The funding bodies did not play any role in the study. J.W. was supported by the University of Melbourne Postgraduate Scholarship and the Murdoch Children's Research Institute PhD Top Up Scholarship. The following authors were supported by the NHMRC: V.S. (Early Career Fellowship [1125687]), P.C. (Centre of Research Excellence in Child Language [1023493]), R.S.L. (Postgraduate Scholarship [1114567]), D.B. (Senior Research Fellowship [1064629]) and M.W. (Senior Research Fellowship [1046518]) in this work. V.S. was additionally supported by a Cottrell Research Fellowship from the Royal Australasian College of Physicians, and M.W. by Cure Kids New Zealand.