Journal article

Impaired social behaviour and molecular mediators of associated neural circuits during chronic Toxoplasma gondii infection in female mice

Shiraz Tyebji, Simona Seizova, Alexandra L Garnham, Anthony J Hannan, Christopher J Tonkin

Brain, Behavior, and Immunity | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2019

Abstract

Toxoplasma gondii (T. gondii) is a neurotropic parasite that is associated with various neuropsychiatric disorders. Rodents infected with T. gondii display a plethora of behavioural alterations, and Toxoplasma infection in humans has been strongly associated with disorders such as schizophrenia, in which impaired social behaviour is an important feature. Elucidating changes at the cellular level relevant to neuropsychiatric conditions can lead to effective therapies. Here, we compare changes in behaviour during an acute and chronic T. gondii infection in female mice. Further, we notice that during chronic phase of infection, mice display impaired sociability when exposed to a novel conspecif..

View full abstract

Grants

Funding Acknowledgements

We would like to thank the expert help of Carolina Alvarado from WEHI Bioservices, Onker Singh from WEHI Engineering department, Ellen Tsui and Cary Tsui form WEHI Histology department, and Lachlan Whitehead and Mark Scott from WEHI's Centre of Dynamic Imaging. We would also like to thank Emma Burrows and Shlomo Yeshurun from Florey Institute of Neuroscience and Mental Health, Melbourne for their useful discussions and support for this work. SS is a recipient of the Australian Government Research Training Program Stipend Scholarship. AJH is an NHMRC Principal Research Fellow. We also gratefully acknowledge The David Winston Turner Endowment for funding this work. We are also grateful for institutional support from the Victorian State Government Operational Infrastructure Support and the Australian Government NHMRC IRIISS.