Journal article

In Vitro Susceptibility of Berberine Combined with Antifungal Agents Against the Yeast Form of Talaromyces marneffei

Hong Luo, Kai-su Pan, Xiao-lu Luo, Dong-yan Zheng, Alex Andrianopoulos, Le-min Wen, Yan-qing Zheng, Jing Guo, Chun-yang Huang, Xiu-ying Li, Rong Hu, Yu-jiao Li, Tian-min Li, Justin Joseph, Cun-wei Cao, Gang Liang



Talaromyces (Penicillium) marneffei can cause fatal disseminated infection in immunocompromised hosts. However, therapeutic strategies for the mycosis are limited. Reports of the other fungi suggest that berberine, a component of traditional herb, inhibitors interact with antifungal agents to improve the treatment outcomes. In the study, we evaluated the in vitro efficacy of berberine in combination with conventional antifungal agents against the pathogenic yeast form of T. marneffei. We demonstrate the synergistic effect of combination of berberine with fluconazole (52.38%), itraconazole (66.67%), voriconazole (71.43%), amphotericin B (71.43%) or caspofungin (52.38%) of T. marneffei strains..

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University of Melbourne Researchers


Awarded by National Natural Science Foundation of China

Awarded by Natural Science Foundation of Guangxi Province of China

Funding Acknowledgements

This study was supported by grants from the National Natural Science Foundation of China (Nos. 81571971 and 81271804) and Natural Science Foundation of Guangxi Province of China (2017GXNSFAA198004 and 20150825). The funders have no role in this study design, data collection and analysis, decision to publish or preparation of the manuscript.