Plasmodium-specific antibodies block in vivo parasite growth without clearing infected red blood cells
Jasmin Akter, David S Khoury, Rosemary Aogo, Lianne IM Lansink, Arya SheelaNair, Bryce S Thomas, Pawat Laohamonthonkul, Clara PS Pernold, Matthew WA Dixon, Megan SF Soon, Lily G Fogg, Jessica A Engel, Trish Elliott, Ismail Sebina, Kylie R James, Deborah Cromer, Miles P Davenport, Ashraful Haque
PLOS PATHOGENS | PUBLIC LIBRARY SCIENCE | Published : 2019
Plasmodium parasites invade and multiply inside red blood cells (RBC). Through a cycle of maturation, asexual replication, rupture and release of multiple infective merozoites, parasitised RBC (pRBC) can reach very high numbers in vivo, a process that correlates with disease severity in humans and experimental animals. Thus, controlling pRBC numbers can prevent or ameliorate malaria. In endemic regions, circulating parasite-specific antibodies associate with immunity to high parasitemia. Although in vitro assays reveal that protective antibodies could control pRBC via multiple mechanisms, in vivo assessment of antibody function remains challenging. Here, we employed two mouse models of antib..View full abstract
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Awarded by National Health & Medical Research Council of Australia
Awarded by Australian Research Council
This work was supported by the National Health & Medical Research Council of Australia (https://nhmrc.gov.au/; Grant numbers 1028643, 1028641, 1126399 to AH; 1082022 to MPD, DC, and AH; 1141921 to DSK; 1080001 to MPD) and the Australian Research Council (https://www.arc.gov.au/; Grant numbers DP180103875 and DP120100064 to MPD, AH, DC, and DSK). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.