Journal article

The immunomodulatory effects of measles-mumps-rubella vaccination on persistence of heterologous vaccine responses

Petra Zimmermann, Kirsten P Perrett, Fiona RM van der Klis, Nigel Curtis

Immunology & Cell Biology | WILEY | Published : 2019

Abstract

It is proposed that measles-containing vaccines have immunomodulatory effects which include a reduction in all-cause childhood mortality. The antibody response to heterologous vaccines provides a means to explore these immunomodulatory effects. This is the first study to investigate the influence of measles-mumps-rubella (MMR) vaccine on the persistence of antibodies to a broad range of heterologous infant vaccinations given in the first year of life. In total, 319 children were included in the study. All infants received routine vaccinations at 6 weeks, 4 and 6 months of age. At 12 months of age, 212 children were vaccinated with MMR and Haemophilus influenzae type b-meningococcus C (Hib-Me..

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Grants

Awarded by Australian National Health and Medical Research Council (NHMRC)


Funding Acknowledgements

This work was supported by the Australian National Health and Medical Research Council (NHMRC) (grants GNT1051228 and GNT1099680), the University of Melbourne (International Research Scholarship to PZ) and the European Society of Paediatric Infectious Diseases (Fellowship to PZ). We thank Susie Germano and Rhian Bonnici for their help with data entry and the processing of blood samples, and NicoleMessina and Kaya Gardiner for project co-ordination. We also thank Professor Andrew Pollard for his helpful comments on themanuscript.