Journal article
Loss of growth hormone–mediated signal transducer and activator of transcription 5 (STAT5) signaling in mice results in insulin sensitivity with obesity
Y Chhabra, CN Nelson, M Plescher, JL Barclay, AG Smith, S Andrikopoulos, S Mangiafico, DJ Waxman, AJ Brooks, MJ Waters
FASEB Journal | WILEY | Published : 2019
Abstract
Growth hormone (GH) has an important function as an insulin antagonist with elevated insulin sensitivity evident in humans and mice lacking a functional GH receptor (GHR). We sought the molecular basis for this sensitivity by utilizing a panel of mice possessing specific deletions of GHR signaling pathways. Metabolic clamps and glucose homeostasis tests were undertaken in these obese adult C57BL/6 male mice, which indicated impaired hepatic gluconeogenesis. Insulin sensitivity and glucose disappearance rate were enhanced in muscle and adipose of mice lacking the ability to activate the signal transducer and activator of transcription (STAT)5 via the GHR (Ghr-391−/−) as for GHR-null (GHR−/−) ..
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Awarded by National Institutes of Health
Funding Acknowledgements
The authors thank The University of Queensland Institute for Molecular Biosciences Animal House Facility for animal husbandry services. The research was supported by National Health and Medical Research Council grants 1083612 (to A.G.S.), 1124026 (to A.J.B.), and 401668 (to M.J.W.). D.J.W. was supported, in part, by U.S. National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases Grant DK033765. The authors declare no conflicts of interest.