Journal article
Distinct gut virome profile of pregnant women with type 1 diabetes in the ENDIA study
KW Kim, DW Allen, T Briese, JJ Couper, SC Barry, PG Colman, AM Cotterill, EA Davis, LC Giles, LC Harrison, M Harris, A Haynes, JL Horton, SR Isaacs, K Jain, WI Lipkin, G Morahan, C Morbey, ICN Pang, AT Papenfuss Show all
Open Forum Infectious Diseases | OXFORD UNIV PRESS INC | Published : 2019
DOI: 10.1093/ofid/ofz025
Abstract
Background. The importance of gut bacteria in human physiology, immune regulation, and disease pathogenesis is well established. In contrast, the composition and dynamics of the gut virome are largely unknown; particularly lacking are studies in pregnancy. We used comprehensive virome capture sequencing to characterize the gut virome of pregnant women with and without type 1 diabetes (T1D), longitudinally followed in the Environmental Determinants of Islet Autoimmunity study. Methods. In total, 61 pregnant women (35 with T1D and 26 without) from Australia were examined. Nucleic acid was extracted from serial fecal specimens obtained at prenatal visits, and viral genomes were sequenced by vir..
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Awarded by Australian Research Council
Funding Acknowledgements
This work was funded by the National Health and Medical Research Council (NHMRC) Practitioner fellowships (APP1045777 [to M. E. C.] and APP1044694 [to W. D. R.]), Juvenile Diabetes Research Foundation Australia (JDRF)/NHMRC Centre of Research Excellence for the Protection of Pancreatic Beta Cells (APP1078106), and the National Institutes of Health (Center for Research in Diagnostics and Discovery) (U19 AI109761 [to T. B. and W. I. L.]). The ENDIA Study is supported by JDRF Australia, the recipient of the Australian Research Council Special Research Initiative in Type 1 Juvenile Diabetes, The Leona M. and Harry B. Helmsley Charitable Trust, JDRF International, and the NHMRC.