Journal article

Casting a wider net: Immunosurveillance by nonclassical MHC molecules

M Patricia D'Souza, Erin Adams, John D Altman, Michael E Birnbaum, Cesar Boggiano, Giulia Casorati, Yueh-hsiu Chien, Anthony Conley, Sidonia Barbara Guiomar Eckle, Klaus Fruh, Timothy Gondre-Lewis, Namir Hassan, Huang Huang, Lakshmi Jayashankar, Anne G Kasmar, Nina Kunwar, Judith Lavelle, David M Lewinsohn, Branch Moody, Louis Picker Show all

PLoS Pathogens | PUBLIC LIBRARY SCIENCE | Published : 2019

Abstract

Most studies of T lymphocytes focus on recognition of classical major histocompatibility complex (MHC) class I or II molecules presenting oligopeptides, yet there are numerous variations and exceptions of biological significance based on recognition of a wide variety of nonclassical MHC molecules. These include αβ and γδ T cells that recognize different class Ib molecules (CD1, MR-1, HLA-E, G, F, et al.) that are nearly monomorphic within a given species. Collectively, these T cells can be considered "unconventional," in part because they recognize lipids, metabolites, and modified peptides. Unlike classical MHC-specific cells, unconventional T cells generally exhibit limited T-cell antigen ..

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University of Melbourne Researchers