Journal article
Challenges and opportunities to prevent tuberculosis in people living with HIV in low-income countries
AD Harries, V Schwoebel, I Monedero-Recuero, TK Aung, S Chadha, CY Chiang, F Conradie, JP Dongo, E Heldal, P Jensen, JPK Nyengele, KG Koura, AMV Kumar, Y Lin, N Mlilo, A Nakanwagi-Mukwaya, RT Ncube, R Nyinoburyo, NL Oo, LN Patel Show all
International Journal of Tuberculosis and Lung Disease | INT UNION AGAINST TUBERCULOSIS LUNG DISEASE (I U A T L D) | Published : 2019
Abstract
People living with the human immunodeficiency virus (HIV) (PLHIV) are at high risk for tuberculosis (TB), and TB is a major cause of death in PLHIV. Preventing TB in PLHIV is therefore a key priority. Early initiation of antiretroviral therapy (ART) in asymptomatic PLHIV has a potent TB preventive effect, with even more benefits in those with advanced immunodeficiency. Applying the most recentWorldHealthOrganization recommendations that all PLHIV initiate ART regardless of clinical stage or CD4 cell count could provide a considerable TB preventive benefit at the population level in high HIV prevalence settings. Preventive therapy can treat tuberculous infection and prevent new infections dur..
View full abstract