Journal article

Retinal regeneration mechanisms linked to multiple cancer molecules: A therapeutic conundrum

Amanda Barber, Kyle Farmer, Keith R Martin, Patrice D Smith

Progress in Retinal and Eye Research | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2017

Abstract

Over the last decade, a large number of research articles have been published demonstrating regeneration and/or neuroprotection of retinal ganglion cells following manipulation of specific genetic and molecular targets. Interestingly, of the targets that have been identified to promote repair following visual system damage, many are genes known to be mutated in different types of cancer. This review explores recent literature on the potential for modulating cancer genes as a therapeutic strategy for visual system repair and looks at the potential clinical challenges associated with implementing this type of therapy. We also discuss signalling mechanisms that have been implicated in cancer an..

View full abstract