Journal article

Influence of Extracellular Matrix Components on the Expression of Integrins and Regeneration of Adult Retinal Ganglion Cells

Elena Vecino, Janosch P Heller, Patricia Veiga-Crespo, Keith R Martin, James W Fawcett

PLoS One | PUBLIC LIBRARY SCIENCE | Published : 2015

Abstract

PURPOSE: Retinal ganglion cells (RGCs) are exposed to injury in a variety of optic nerve diseases including glaucoma. However, not all cells respond in the same way to damage and the capacity of individual RGCs to survive or regenerate is variable. In order to elucidate factors that may be important for RGC survival and regeneration we have focussed on the extracellular matrix (ECM) and RGC integrin expression. Our specific questions were: (1) Do adult RGCs express particular sets of integrins in vitro and in vivo? (2) Can the nature of the ECM influence the expression of different integrins? (3) Can the nature of the ECM affect the survival of the cells and the length or branching complexit..

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Grants

Awarded by Grupos Consolidados Gobierno Vasco


Awarded by Medical Research Council


Awarded by International Spinal Research Trust


Awarded by Fight for Sight


Funding Acknowledgements

Financial support was provided by Grupos Consolidados Gobierno Vasco (IT437-10), Basque Country Goberment/Clare Hall Fellowship to EV, Fight for Sight and the Jukes Glaucoma Research Foundation to KRM, and Medical Reseach Council (GB) to JWF.