Glial cell interactions and glaucoma
Rachel S Chong, Keith R Martin
Current Opinion in Ophthalmology | LIPPINCOTT WILLIAMS & WILKINS | Published : 2015
PURPOSE OF REVIEW: The present review describes new advances in our understanding of the role of glial cells in the pathogenesis of glaucoma. It is becoming clear that retinal glia should not be studied in isolation in glaucoma because glia have dynamic and diverse interactions with a range of different cell types that could influence the disease process. RECENT FINDINGS: Microglial activity is modulated by signals from retinal ganglion cells and macroglia that influence RGC survival in various models of injury. New studies suggest that circulating monocytic populations may play a role in mediating the immune response to glaucoma. Astrocytes have been found to develop discrete localized proc..View full abstract
The authors were supported by the Agency for Science, Technology and Research (Singapore), Fight for Sight (UK), the Cambridge Eye Trust (UK) and the Jukes Glaucoma Research Fund (UK).