Journal article
Neuroprotective effects of intravitreal mesenchymal stem cell transplantation in experimental glaucoma
TV Johnson, ND Bull, DP Hunt, N Marina, SI Tomarev, KR Martin
Investigative Ophthalmology and Visual Science | ASSOC RESEARCH VISION OPHTHALMOLOGY INC | Published : 2010
DOI: 10.1167/iovs.09-4509
Abstract
PURPOSE. Retrograde neurotrophic factor transport blockade has been implicated in the pathophysiology of glaucoma. Stem cell transplantation appears to ameliorate some neurodegenerative conditions in the brain and spinal cord, in part by neurotrophic factor secretion. The present study was conducted to determine whether local or systemic bone marrowderived mesenchymal stem cell (MSC) transplantation can confer neuroprotection in a rat model of laser-induced ocular hypertensive glaucoma. METHODS. MSCs were isolated from the bone marrow of adult wild-type and transgenic rats that ubiquitously express green fluorescent protein. MSCs were transplanted intravitreally 1 week before, or intravenous..
View full abstractGrants
Awarded by National Eye Institute
Funding Acknowledgements
Supported by a GSK Clinician Scientist Fellowship (KRM); a Fight for Sight (UK) research grant (NDB); a National Institutes of Health OxCam Scholarship (TVJ); the Gates-Cambridge Trust (TVJ); Cambridge University Hospitals NHS Foundation Trust; the Richard Norden Glaucoma Research Fund; Fight for Sight (UK); and the National Eye Institute Intramural Research Program.