Journal article

An examination of orbitofrontal sulcogyral morphology in obsessive-compulsive disorder

Rebekah Delahoy, Cali F Bartholomeusz, Hugh Pemberton, Pino Alonso, Jesus Pujol, Narcis Cardoner, Jose M Menchon, Caries Soriano-Mas, Ben J Harrison

PSYCHIATRY RESEARCH-NEUROIMAGING | ELSEVIER IRELAND LTD | Published : 2019

Abstract

Obsessive-compulsive disorder (OCD) has been consistently associated with structural and functional alteration of the orbitofrontal cortex (OFC) and its subcortical connections. In exploring these alterations, a neurodevelopmental basis to OCD has been suggested. While some studies have examined outcomes of early cortical maturation processes, such as global cortical thickness and gyrification, no work has specifically examined the OFC. Within the OFC, three types of sulcogyral patterns have been identified as a result of variance in cortical folding. The distribution of these patterns has been found to differ in patients of various neuropsychiatric disorders relative to the general populati..

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Grants

Awarded by Carlos III Health Institute


Awarded by FEDER funds/European Regional Development Fund (ERDF) - a way to build Europe-and AGAUR


Awarded by National Health and Medical Research Council of Australia (NHMRC) Clinical Career Development Award


Awarded by 'Miguel Servet' contract from the ISCIII


Funding Acknowledgements

This study was supported in part by grants from the Carlos III Health Institute (PI13/01958, PI14/00413, PI16/00889, and PI19/016), FEDER funds/European Regional Development Fund (ERDF) - a way to build Europe-and AGAUR (2017 SGR 1247). BJH is supported by a National Health and Medical Research Council of Australia (NHMRC) Clinical Career Development Award (1124472).CS-M is supported by a 'Miguel Servet' contract from the ISCIII (CPII16/00048).