Journal article

Comparing Individual-Based Approaches to Modelling the Self-Organization of Multicellular Tissues

James Osborne, Alexander Fletcher, Joseph Pitt-Francis, Philip Maini, David Gavaghan

Published : 2016

Abstract

Abstract The coordinated behaviour of populations of cells plays a central role in tissue growth and renewal. Cells react to their microenvironment by modulating processes such as movement, growth and proliferation, and signalling. Alongside experimental studies, computational models offer a useful means by which to investigate these processes. To this end a variety of cell-based modelling approaches have been developed, ranging from lattice-based cellular automata to lattice-free models that treat cells as point-like particles or extended shapes. It is difficult to accurately compare between different modelling approaches, since one cannot distinguish between differences in behaviour due to..

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University of Melbourne Researchers

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