Modulation of cognitive cerebello-cerebral functional connectivity by lateral cerebellar continuous theta burst stimulation
Anuj Rastogi, Robin Cash, Katharine Dunlop, Michael Vesia, Aaron Kucyi, Ayda Ghahremani, Jonathan Downar, Joyce Chen, Robert Chen
NEUROIMAGE | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2017
Network connectivity measured with resting state functional magnetic resonance imaging (rsfMRI) has revealed the contribution of distinct cerebellar lobules to an array of brain wide networks sub-serving motor and cognitive processes. As distinct cerebellar lobules form relatively accessible nodes of different brain networks, this raises the possibility for site-specific modulation of network connectivity using non-invasive brain stimulation techniques such as transcranial magnetic stimulation (TMS). Continuous theta burst transcranial magnetic stimulation (cTBS) induces long-lasting inhibition of cortical areas. Although previous studies have shown that cTBS of the lateral cerebellum modula..View full abstract
Awarded by Canadian Institutes of Health Research (CIHR)
The study was funded by the Canadian Institutes of Health Research (CIHR) grants MOP 123396 and 15128. KD was funded by the CIHR Vanier Scholarship. MV was supported by post-doctoral fellowship from Natural Sciences and Engineering Research Council of Canada (NSERC). We would like to thank Dr. Antonio Strafella and Dr. Karen Davis for insightful discussion, our MRI technician Keith Ta for collecting all scan data, and Carolyn Gunraj for recruiting study participants.