Journal article

Modulation of corticomotor excitability by an I-wave intervention delivered during low-level voluntary contraction.

BI Silbert, JT Gibbons, RHF Cash, FL Mastaglia, GW Thickbroom

Exp Brain Res | Published : 2011


Transcranial magnetic stimulation (TMS) interventions that modulate cortical plasticity may achieve a more functional benefit if combined with neuro-rehabilitation therapies. With a TMS protocol targeting I-wave dynamics, it is possible to deliver stimuli while a subject performs a motor task, and this may more effectively target functional networks related to the task. However, the efficacy of this intervention during a simple task such as a low-level voluntary contraction is not known. We delivered paired-pulse TMS at an inter-pulse interval (IPI) of 1.5 ms for 15 min while subjects performed a 10 ± 2.5% voluntary contraction of the first dorsal interosseous (FDI) muscle and made motor evo..

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University of Melbourne Researchers