Journal article

Early respiratory viral infections in infants with cystic fibrosis

Ashley R Deschamp, Joseph E Hatch, James E Slaven, Netsanet Gebregziabher, Gregory Storch, Graham L Hall, Stephen Stick, Sarath Ranganathan, Thomas W Ferkol, Stephanie D Davis

Journal of Cystic Fibrosis | ELSEVIER | Published : 2019

Abstract

BACKGROUND: Viral infections contribute to morbidity in cystic fibrosis (CF), but the impact of respiratory viruses on the development of airway disease is poorly understood. METHODS: Infants with CF identified by newborn screening were enrolled prior to 4 months of age to participate in a prospective observational study at 4 centers. Clinical data were collected at clinic visits and weekly phone calls. Multiplex PCR assays were performed on nasopharyngeal swabs to detect respiratory viruses during routine visits and when symptomatic. Participants underwent bronchoscopy with bronchoalveolar lavage (BAL) and a subset underwent pulmonary function testing. We present findings through 8.5 months..

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Grants

Awarded by National Institutes of Health (NIH)


Awarded by National Health and Medical Research Council


Funding Acknowledgements

The authors were supported by the National Institutes of Health (NIH) grants, HL116211 (SDD, TWF, SR), National Health and Medical Research Council award, NHMRC1043768, NHMRC1000896 (SMS), NHMRCAPP1025550 (GLH), the Cystic Fibrosis Foundation Fellowship Training Grant (ARD), the Indiana Physician Scientist Award (Eli Lilly) (SDD), and the Royal Children's Hospital Cystic Fibrosis Research Trust (SR). The views expressed do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S government.