Changing Prevalence of Lower Airway Infections in Young Children with Cystic Fibrosis
Oded Breuer, Andre Schultz, Lidija Turkovic, Nicholas de Klerk, Anthony D Keil, Siobhain Brennan, Joanne Harrison, Colin Robertson, Philip J Robinson, Peter D Sly, Sarath Ranganathan, Stephen M Stick, Daan Caudri
American Journal of Respiratory and Critical Care Medicine | AMER THORACIC SOC | Published : 2019
RATIONALE: Historical studies suggest that airway infection in cystic fibrosis (CF) initiates with Staphylococcus aureus and Haemophilus influenzae with later emergence of Pseudomonas aeruginosa. Aspergillus species are regarded as relatively infrequent, late occurring infections. OBJECTIVES: To assess the prevalence and change in prevalence of early lower airway infections in a modern cohort of children with CF. METHODS: All infants diagnosed with CF after newborn screening, participating in the AREST-CF cohort study between 2000-2018, were included. Participants prospectively underwent bronchoalveolar lavage (BAL) at 3-6 months,1 year and annually up to 6 years of age. Lower airway infecti..View full abstract
Awarded by National Health and Medical Research Council (NHMRC)
Australian Respiratory Early Surveillance Team for Cystic Fibrosis (AREST CF) is supported by Cystic Fibrosis Foundation Therapeutics, Inc., USA and Cystic Fibrosis Australia, as well as by National Health and Medical Research Council (NHMRC) grants APP1000896 and 1020555. O.B. has been supported by a Lowy Foundation Pediatric Fellowship arranged by AUSiMED (Australia/Israel Medical Research). D.C. received support for a research fellowship from the Rothwell Foundation, the Ter Meulen Grant of the Royal Netherlands Academy of Arts and Sciences, and the Sophia Children's Hospital Fund. None of the funding bodies were in any way involved in the data collection, interpretation of the data, or writing of the manuscript. S.M.S. is an NHMRC Practitioner Fellow and received support from Northern Star Resources.