Journal article
Changing prevalence of lower airway infections in young children with cystic fibrosis
O Breuer, A Schultz, L Turkovic, N De Klerk, AD Keil, S Brennan, J Harrison, C Robertson, PJ Robinson, PD Sly, S Ranganathan, SM Stick, D Caudri
American Journal of Respiratory and Critical Care Medicine | AMER THORACIC SOC | Published : 2019
Abstract
Rationale: Historical studies suggest that airway infection in cystic fibrosis initiates with Staphylococcus aureus and Haemophilus influenzae, with later emergence of Pseudomonas aeruginosa. Aspergillus species are regarded as relatively infrequent, lateoccurring infections. Objectives: To assess the prevalence and change in prevalence of early lower airway infections in a modern cohort of children with cystic fibrosis. Methods: All infants diagnosed with cystic fibrosis after newborn screening participating in the Australian Respiratory Early Surveillance Team for Cystic Fibrosis (AREST CF) cohort study between 2000 and 2018 were included. Participants prospectively underwent BAL at 3-6 mo..
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Awarded by Cystic Fibrosis Foundation
Funding Acknowledgements
Australian Respiratory Early Surveillance Team for Cystic Fibrosis (AREST CF) is supported by Cystic Fibrosis Foundation Therapeutics, Inc., USA and Cystic Fibrosis Australia, as well as by National Health and Medical Research Council (NHMRC) grants APP1000896 and 1020555. O.B. has been supported by a Lowy Foundation Pediatric Fellowship arranged by AUSiMED (Australia/Israel Medical Research). D.C. received support for a research fellowship from the Rothwell Foundation, the Ter Meulen Grant of the Royal Netherlands Academy of Arts and Sciences, and the Sophia Children's Hospital Fund. None of the funding bodies were in any way involved in the data collection, interpretation of the data, or writing of the manuscript. S.M.S. is an NHMRC Practitioner Fellow and received support from Northern Star Resources.