Journal article

Reducing lung liquid volume increases biventricular outputs and systemic arterial blood flows despite decreased cardiac filling pressures in fetal lambs

Joseph J Smolich, Jonathan P Mynard

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology | American Physiological Society | Published : 2019

Abstract

As prior work has shown that reducing lung liquid volume 1) increases pulmonary arterial (PA) blood flow, 2) augments right ventricular (RV) output/power, and 3) decreases left atrial (LA) pressure, we tested the hypothesis that this perturbation has global cardiovascular effects. Ten anesthetized, open-chest fetal lambs (128 ± 2 days gestation, full term = 147 days) were acutely instrumented with 1) LA and right atrial (RA) catheters, 2) aortic and pulmonary trunk catheters, 3) brachiocephalic trunk, aortic isthmus, ductal, and left PA flow probes to obtain left ventricular (LV) and RV outputs and hydraulic power and flow in the descending thoracic aorta, and 4) an endotracheal tube to remo..

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Grants

Awarded by National Heart Foundation of Australia


Awarded by National Health and Medical Research Council of Australia


Funding Acknowledgements

This work was supported by National Heart Foundation of Australia Grant-in-Aid G12M6372, National Health and Medical Research Council of Australia Project Grant 1105137, and the Victorian Government's Operational Infrastructure Support Program. J. P. Mynard was supported by a cofunded Career Development Fellowship/Future Leader Fellowship from the National Health and Medical Research Council of Australia and National Heart Foundation of Australia.