Journal article

Evolution of carbapenem resistance in Acinetobacter baumannii during a prolonged infection

Jane Hawkey, David Ascher, Louise Judd, Ryan Wick, Xenia Kostoulias, Heather Cleland, Denis Spelman, Alex Padiglione, Anton Peleg, Kathryn Holt

Published : 2017

Abstract

ABSTRACT Acinetobacter baumannii is a common causative agent of hospital-acquired infections and a leading cause of infection in burns patients. Carbapenem resistant A. baumannii is considered a major public health threat and has been identified by the World Health Organization as the top priority organism requiring new antimicrobials. The most common mechanism for carbapenem resistance in A. baumannii is via horizontal acquisition of carbapenemase genes. In this study, we sampled 20 A. baumannii isolates from a patient with extensive burns, and characterized the evolution of carbapenem resistance over a 45-day period via Illumina and Oxford Nanopore sequencing. All isolates were multi-drug ..

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