Journal article
SGLT2 Inhibitors Increase the Risk of Diabetic Ketoacidosis Developing in the Community and during Hospital Admission
PS Hamblin, R Wong, EI Ekinci, S Fourlanos, S Shah, AR Jones, MJL Hare, GL Calder, DS Epa, EM George, R Giri, MA Kotowicz, M Kyi, N Lafontaine, RJ Macisaac, BJ Nolan, DN O'Neal, D Renouf, S Varadarajan, J Wong Show all
Journal of Clinical Endocrinology and Metabolism | ENDOCRINE SOC | Published : 2019
Abstract
Context Diabetic ketoacidosis (DKA) has been associated with the use of sodium glucose cotransporter 2 inhibitors (SGLT2is). Objective To determine the incidence, characteristics, and outcomes of DKA in SGLT2i users vs nonusers with type 2 diabetes. Design Retrospective, multicenter, controlled cohort study. Setting All public hospitals in Melbourne and Geelong (combined population of 5 million), Australia, from 1 September 2015 to 31 October 2017. Patients Consecutive cases of DKA that developed in the community, or during the course of hospital admission, in patients with type 2 diabetes Main Outcome Measures In SGLT2i users vs nonusers: (i) OR of DKA developing during hospital admission, ..
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