Conference Proceedings

Obesity does not alter endometrial gene expression in women with endometriosis

Sarah J Holdsworth-Carson, Jessica Chung, Clare Sloggett, Sally Mortlock, Jenny N Fung, Grant W Montgomery, Uri P Dior, Martin Healey, Peter AW Rogers, Jane E Girling

REPRODUCTIVE BIOMEDICINE ONLINE | ELSEVIER SCI LTD | Published : 2020

Abstract

RESEARCH QUESTION: Does obesity affect endometrial gene expression in women with endometriosis, specifically women with stage I disease? DESIGN: Differential gene expression analysis was conducted on endometrium from women with and without endometriosis (n = 169). Women were diagnosed after surgical visualization and staged according to the revised American Society for Reproductive Medicine (stage I-IV). Women were grouped by body mass index (BMI) (kg/m2) as underweight, normal, pre-obese or obese. After accounting for menstrual cycle stage, endometrial gene expression was analysed by BMI (continuous and grouped) in women with endometriosis, and in non-endometriosis controls. RESULTS: No sig..

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