Journal article

Methods for the Detection of Seizure Bursts in Epilepsy

Udaya Seneviratne, Philippa Karoly, Dean R Freestone, Mark J Cook, Ray C Boston

Frontiers in Neurology | FRONTIERS MEDIA SA | Published : 2019

Abstract

Background: Seizure clusters and “bursts” are of clinical importance. Clusters are reported to be a marker of antiepileptic drug resistance. Additionally, seizure clustering has been found to be associated with increased morbidity and mortality. However, there are no statistical methods described in the literature to delineate bursting phenomenon in epileptic seizures. Methods: We present three automatic burst detection methods referred to as precision constrained grouping (PCG), burst duration constrained grouping (BCG), and interseizure interval constrained grouping (ICG). Concordance correlation coefficients were used to confirm the pairwise agreement between common bursts isolated using..

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