Journal article
Orthostatic hypotension and cognition in older adults: A systematic review and meta-analysis
R Iseli, VTV Nguyen, S Sharmin, EM Reijnierse, WK Lim, AB Maier
Experimental Gerontology | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2019
Abstract
Background: Orthostatic hypotension (OH) is common in older adults with reported prevalence rates of 5–40%. A direct link between OH and cognitive performance has been proposed due to impaired vascular autoregulation. Aim: To systematically assess the literature of the association between OH and cognitive performance in older adults. Methods: Literature search of MEDLINE, Embase, Cochrane Central Register of Controlled Trials and PsycINFO from inception to May 2017. Studies were included if OH and cognition were assessed in subjects of mean or median age ≥65 years. Risk of bias was assessed with the Newcastle Ottawa Scale. Results: Of 3266 studies screened, 32 studies (22 cross-sectional; 10..
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Awarded by European Commission
Funding Acknowledgements
This study has received funding from the perspective grant (NeuroCIMT) of the Applied and Engineering Sciences, which is part of the Netherlands Organisation for Scientific Research (Utrecht, the Netherlands) and which is partly funded by the Ministry of Economic Affairs. Furthermore, this study received funding from the European Union's Horizon 2020 research and innovation programme: PreventIT (No. 689238) and PANINI (No. 675003). The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.