Journal article
Cyclin E1 expression and palbociclib efficacy in previously treated hormone receptor-positive metastatic breast cancer
NC Turner, Y Liu, Z Zhu, S Loi, M Colleoni, S Loibl, A DeMichele, N Harbeck, F André, MAM Bayar, SP Michiels, Z Zhang, C Giorgetti, M Arnedos, CH Bartlett, M Cristofanilli
Journal of Clinical Oncology | AMER SOC CLINICAL ONCOLOGY | Published : 2019
DOI: 10.1200/JCO.18.00925
Open access
Abstract
PURPOSE A large-panel gene expression analysis was conducted to identify biomarkers associated with the effectiveness of adding palbociclib to fulvestrant. METHODS The PALOMA-3 (ClinicalTrials.gov identifier: NCT01942135) trial randomly assigned 521 endocrinepretreated patients with metastatic breast cancer to receive palbociclib plus fulvestrant or placebo plus fulvestrant. Primary analysis was first conducted on 10 genes on the basis of pathway biology and evidence from previous studies followed by a systematic panel-wide search among 2,534 cancer-related genes. The association of gene expression with the effect of palbociclib on progression-free survival (PFS) was evaluated using Cox prop..
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Funding Acknowledgements
Supported by Pfizer. The Preoperative Palbociclib trial was sponsored by and analyzed at Institut Gustave Roussy. Editorial support was provided by Anny Wu, PharmD, of Complete Healthcare Communications (North Wales, PA), a CHC Group company, and was funded by Pfizer.