Conference Proceedings
PRMT5 Inhibition Selectively Targets Acute Myeloid Leukemia Stem Cells Though a p53-Dependent Mechanism
Emma Toulmin, Stefan Sonderegger, Loretta Cerruti, Andrej Terzic, Feng Yan, Nicholas Wong, Ian Street, Paul Stupple, Stephen Jane, Andrew H Wei, Rachel Altura, Benjamin Nicholson, David J Curtis
BLOOD | AMER SOC HEMATOLOGY | Published : 2018
Abstract
Abstract Background: Targeting leukemic stem cells without detrimental effects on hematopoietic stem cells is a major goal for improving cure rates for acute myeloid leukemia (AML). Strategies include targeting leukemia specific mutations or pathways where leukemic cells are more dependent, leading to so-called synthetic lethality. One potential target for the latter is PRMT5, an arginine methyltransferase that methylates arginine on histones and a large number of non-histone proteins including components of the spliceosome. PRMT5 is essential for the maintenance of normal hematopoietic stem cells, through p53-dependent and independent mechanisms. Aim: To determ..
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