IL-36 gamma regulates mediators of tissue homeostasis in epithelial cells
Jacqueline E Heath, Glen M Scholz, Paul D Veith, Eric C Reynolds
CYTOKINE | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD | Published : 2019
IL-36 cytokines are critical regulators of mucosal inflammation and homeostasis. IL-36γ regulates the expression of inflammatory cytokines and antimicrobial proteins by gingival epithelial cells (e.g. TIGK cells). Here, we show that IL-36γ also regulates the expression of matrix metalloproteinase 9 (MMP9) and neutrophil gelatinase-associated lipocalin (NGAL), important mediators of antimicrobial immunity and tissue homeostasis in mucosal epithelia. MMP9 and NGAL were not similarly induced by IL-17 or IL-22, thus indicating the importance of IL-36γ in the regulation of MMP9 and NGAL. Mechanistically, MMP9 and NGAL expression was demonstrated to be induced in an IRAK1- and NF-κB-dependent mann..View full abstract
Awarded by Australian Government, Department of Industry, Innovation and Science
This research was supported by the Australian Government, Department of Industry, Innovation and Science Grant ID 20080108.