Journal article
Effect of methylprednisolone on acute kidney injury in patients undergoing cardiac surgery with a cardiopulmonary bypass pump: A randomized controlled trial
AX Garg, MTV Chan, MS Cuerden, PJ Devereaux, SH Abbasi, A Hildebrand, F Lamontagne, A Lamy, N Noiseux, CR Parikh, V Perkovic, M Quantz, A Rochon, A Royse, DI Sessler, PJ Shah, JM Sontrop, GI Tagarakis, KH Teoh, J Vincent Show all
CMAJ | CMA-CANADIAN MEDICAL ASSOC | Published : 2019
DOI: 10.1503/cmaj.181644
Abstract
BACKGROUND: Perioperative corticosteroid use may reduce acute kidney injury. We sought to test whether methylprednisolone reduces the risk of acute kidney injury after cardiac surgery. METHODS: We conducted a prespecified substudy of a randomized controlled trial involving patients undergoing cardiac surgery with cardiopulmonary bypass (2007–2014); patients were recruited from 79 centres in 18 countries. Eligibility criteria included a moderate-to-high risk of perioperative death based on a preoperative score of 6 or greater on the European System for Cardiac Operative Risk Evaluation I. Patients (n = 7286) were randomly assigned (1:1) to receive intravenous methylprednisolone (250 mg at ane..
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Awarded by National Institutes of Health
Funding Acknowledgements
The Steroids in Cardiac Surgery (SIRS) trial and this substudy on acute kidney injury were financially supported by grants from the Canadian Institutes of Health Research (CIHR). Amit Garg was supported by the Dr. Adam Linton Chair in Kidney Health Analytics and a CIHR Clinician Investigator Award. Chirag Parikh was supported by the National Institutes of Health grant RO1HL-085757. Michael Walsh is supported by a CIHR New Investigator Award.