Journal article

Missense Variants in the Histone Acetyltransferase Complex Component Gene TRRAP Cause Autism and Syndromic Intellectual Disability

Benjamin Cogne, Sophie Ehresmann, Eliane Beauregard-Lacroix, Justine Rousseau, Thomas Besnard, Thomas Garcia, Slave Petrovski, Shiri Avni, Kirsty McWalter, Patrick R Blackburn, Stephan J Sanders, Kevin Uguen, Jacqueline Harris, Julie S Cohen, Moira Blyth, Anna Lehman, Jonathan Berg, Mindy H Li, Usha Kini, Shelagh Joss Show all

The American Journal of Human Genetics | CELL PRESS | Published : 2019

University of Melbourne Researchers

Grants

Awarded by French Ministry of Health from Poitou-Charentes (HUGODIMS)


Awarded by Health Regional Agency from Poitou-Charentes (HUGODIMS)


Awarded by National Institute of Neurological Disorders and Stroke (The Epilepsy Phenome/Genome Project)


Awarded by National Institutes of Health/Eunice Kennedy Shriver National Institute of Child Health and Human Development grant


Awarded by NINDS


Awarded by National Human Genome Research Institute (NHGRI)


Awarded by National Heart, Lung, and Blood Institute (NHLBI)


Awarded by NHGRI


Awarded by intramural research program of the NHGRI


Awarded by US National Institute of Mental Health


Awarded by NATIONAL HUMAN GENOME RESEARCH INSTITUTE


Awarded by NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES


Awarded by NATIONAL INSTITUTE OF MENTAL HEALTH


Awarded by NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE


Funding Acknowledgements

We would like to thank all families for participating in this study. This work was supported in part by grants from: the French Ministry of Health and the Health Regional Agency from Poitou-Charentes (HUGODIMS, 2013, RC14_0107) to S.B.; the National Institute of Neurological Disorders and Stroke (The Epilepsy Phenome/Genome Project NS053998; Epi4K NS077364, NS077274, NS077303, and NS077276) to D.L. and D.B.G.; the National Institutes of Health/Eunice Kennedy Shriver National Institute of Child Health and Human Development grant (HD064667) to D.A.S.; NINDS R35 NS105078 to J.R.L.; the National Human Genome Research Institute (NHGRI) and National Heart, Lung, and Blood Institute (NHLBI) to the Baylor-Hopkins Center for Mendelian Genomics (UM1 HG006542); NHGRI K08 HG008986 to J.E.P.; the Duke Genome Sequencing Clinic to V.S. and J.S.; the intramural research program of the NHGRI (grant HG200328 12) to L.G.B., J. J. J., and J.C.S.; the US National Institute of Mental Health grant R01MH101221 to E.E.E.; the Kids Brain Health Network and Dart NeuroScience to F.B.; and Mining for Miracles, British Columbia Children's Hospital Foundation, and Genome British Columbia to the CAUSES Study. We thank the Canadian Institutes of Health Research (CIHR) and Fonds de la recherche en sante du Quebec (FRSQ) for clinician-scientist awards to P.M.C.; and the Mayo Clinic Center for Individualized Medicine (CIM) for supporting this research through the CIM Investigative and Functional Genomics Program. We are grateful to the members of the Canadian Center for Computational Genomics and the McGill University and Genome Quebec Innovation Center for their help in bioinformatics analysis.