Journal article
Cross-border movement of highly drug-resistant Mycobacterium tuberculosis from papua new guinea to Australia through torres strait protected zone, 2010-2015
A Bainomugisa, S Pandey, E Donnan, G Simpson, J Foster, E Lavu, S Hiasihri, ES McBryde, R Moke, S Vincent, V Sintchenko, BJ Marais, LJM Coin, C Coulter
Emerging Infectious Diseases | CENTERS DISEASE CONTROL | Published : 2019
Abstract
In this retrospective study, we used whole-genome sequencing (WGS) to delineate transmission dynamics, characterize drug-resistance markers, and identify risk factors of transmission among Papua New Guinea residents of the Torres Strait Protected Zone (TSPZ) who had tuberculosis diagnoses during 2010-2015. Of 117 isolates collected, we could acquire WGS data for 100; 79 were Beijing sublineage 2.2.1.1, which was associated with active transmission (odds ratio 6.190, 95% CI 2.221-18.077). Strains were distributed widely throughout the TSPZ. Clustering occurred more often within than between villages (p = 0.0013). Including 4 multidrug-resistant tuberculosis isolates from Australia citizens ep..
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Funding Acknowledgements
This research was supported by NeCTAR Research Cloud, Queensland Cyber Infrastructure Foundation and University of Queensland's Research Computing Centre. The NeCTAR Research Cloud is a collaborative Australian research platform supported by the National Collaborative Research Infrastructure Strategy.