Particokinetics and in vitro dose of high aspect ratio nanoparticles
Seth Richard Price, Calum Kinnear, Sandor Balog
NANOSCALE | ROYAL SOC CHEMISTRY | Published : 2019
Computational particokinetics models become essential in the design and interpretation of in vitro nanoparticle toxicology assays involving submerged adherent cell cultures. Yet, none of the current models offers the possibility of addressing the delivered dose of high-aspect ratio nanoparticles, including nanorods, nanotubes, and nanofibers. Here we present a straightforward method that lends this ability to any of the models used currently.
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Awarded by ARC
S. R. P. and S. B. acknowledge the financial support of the Swiss National Science Foundation through the National Centre of Competence in Research Bio-Inspired Materials. S. B. is also grateful for the financial support of the Adolphe Merkle Foundation and the University of Fribourg. C. K. acknowledges the ARC for support through CE170100026 and a ResearchPlus Postdoctoral Fellowship (CSIRO Manufacturing). Regarding the CNCs and their electron microscopy, the authors gratefully acknowledge the support of Jens Natterodt.