Journal article

Particokinetics and in vitro dose of high aspect ratio nanoparticles

Seth Richard Price, Calum Kinnear, Sandor Balog

NANOSCALE | ROYAL SOC CHEMISTRY | Published : 2019

Abstract

Computational particokinetics models become essential in the design and interpretation of in vitro nanoparticle toxicology assays involving submerged adherent cell cultures. Yet, none of the current models offers the possibility of addressing the delivered dose of high-aspect ratio nanoparticles, including nanorods, nanotubes, and nanofibers. Here we present a straightforward method that lends this ability to any of the models used currently.

University of Melbourne Researchers

Grants

Awarded by ARC


Funding Acknowledgements

S. R. P. and S. B. acknowledge the financial support of the Swiss National Science Foundation through the National Centre of Competence in Research Bio-Inspired Materials. S. B. is also grateful for the financial support of the Adolphe Merkle Foundation and the University of Fribourg. C. K. acknowledges the ARC for support through CE170100026 and a ResearchPlus Postdoctoral Fellowship (CSIRO Manufacturing). Regarding the CNCs and their electron microscopy, the authors gratefully acknowledge the support of Jens Natterodt.