Journal article
A Regulatory Circuit Controlling the Dynamics of NFκB cRel Transitions B Cells from Proliferation to Plasma Cell Differentiation
K Roy, S Mitchell, Y Liu, S Ohta, YS Lin, MO Metzig, SL Nutt, A Hoffmann
Immunity | CELL PRESS | Published : 2019
Abstract
Antibody production requires proper phasing of B cell proliferation and differentiation. Using an iterative systems biology approach, Roy et al. reveal that, although NFκB cRel enables proliferation, it must be downregulated during differentiation. Multi-scale modeling shows how coordinated cRel and RelA dynamics control B cell populations in health and disease.
Grants
Awarded by National Institute of Allergy and Infectious Diseases
Funding Acknowledgements
We thank Sherie Morrison (University of California, Los Angeles [UCLA]) for the generous gift of BCL1 cell line, Lynn Corcoran (Walter and Eliza Hall Institute [WEHI]) and Meinrad Busslinger (Research Institute of Molecular Pathology [IMP Vienna]) for depositing high-quality datasets, Dinesh Rao (UCLA) for helpful discussions, and the Johnson Comprehensive Cancer Center Flow Cytometry Core Facility (UCLA) for expert support. S.L.N. was supported by National Health and Medical Research Council of Australia grants (1054925 and 1058238). This work was supported by a grant from the NIH National Institute of Allergy and Infectious Diseases (R01AI132731) to A.H.