Journal article
Sensing of physiological regulators by innate lymphoid cells
C Seillet, N Jacquelot
Cellular and Molecular Immunology | CHIN SOCIETY IMMUNOLOGY | Published : 2019
Open access
Abstract
Maintenance of homeostasis and immune protection rely on the coordinated action of different physiological systems. Bidirectional communication between the immune system and physiological systems is required to sense and restore any disruption of equilibrium. Recent transcriptomic analyses of innate lymphoid cells (ILCs) from different tissues have revealed that ILCs express a large array of receptors involved in the recognition of neuropeptides, hormones and metabolic signals. ILCs rapidly secrete effector cytokines that are central in the development and activation of early immune responses, but they also constitutively secrete mediators that are important for tissue homeostasis. To achiev..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
The authors apologize to all investigators whose works were not cited in this article due to space limitations. We are grateful to Kylie Luong for helpful comments and preparation of the manuscript. The figure was drawn using Servier Medical Art (https://smart.servier.com) and modified by the authors under the terms of the Creative Commons Attribution 3.0 Unported License. C.S. was supported by grants and fellowships from the National Health and Medical Research Council (NHMRC) of Australia (APP1165443) and the Australian Research Career Development Fellowship (APP1123000). N.J. was supported by Grant 1163990 awarded through the 2018 Priority-driven Collaborative Cancer Research Scheme and cofunded by Cancer Australia and Cure Cancer. This work was made possible through the Victorian State Government Operational Infrastructure Support and the Australian Government NHMRC IRIIS.