Biomarke circulating 25-hydroxyvitamin D concentration & prevent and risk of breast, prostate, and colorectal cancers: The Melbourne Collaborative Cohort study

AK Heath; AM Hodge; PR Ebeling; DW Eyles; D Kvaskoff; DD Buchanan; GG Giles; EJ Williamson; DR English

Journal article

Biomarke circulating 25-hydroxyvitamin D concentration & prevent and risk of breast, prostate, and colorectal cancers: The Melbourne Collaborative Cohort study

AK Heath, AM Hodge, PR Ebeling, DW Eyles, D Kvaskoff, DD Buchanan, GG Giles, EJ Williamson, DR English

Cancer Epidemiology Biomarkers and Prevention | AMER ASSOC CANCER RESEARCH | Published : 2019

DOI: 10.1158/1055-9965.EPI-18-1155

Abstract

Background: The role of vitamin D in cancer risk remains controversial, and limited data exist on associations between vitamin D and subtypes of specific cancers. We investigated associations between circulating 25-hydroxyvitamin D (25(OH)D) and risk of colorectal, breast, and prostate cancers, including subtypes. Methods: A case–cohort study within the Melbourne Collaborative Cohort Study included 547 colorectal, 634 breast, and 824 prostate cancers, and a sex-stratified random sample of participants (n ¼ 2,996). Concentration of 25(OH)D in baseline-dried blood spots was measured using LC-MS/MS. Cox regression yielded adjusted HRs and 95% confidence intervals (CI) for each cancer in relatio..

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University of Melbourne Researchers

Allison Hodge Author

Daniel Buchanan Author

Graham Giles Author

Dallas English Author

Related Projects (3)

NON-LEAD GRANT W/ CANCER COUNCIL VIC - VITAMIN D AND RISK OF CANCER AND MORTALITY IN THE MELBOURNE COLLABORATIVE COHORT STUDY

Overseas studies indicate that vitamin D might protect against certain cancers and other diseases such as heart disease and diabetes. Vitami..

THE HEALTH 2020 COHORT STUDY (HEALTH 2020)

Our aim is to develop appropriate infrastructures necessary to facilitate access by researchers to the accumulated data, including questionn..

Epidemiology of chronic disease, health interventions and DNA studies

Grants

Funding Acknowledgements

MCCS cohort recruitment was funded by VicHealth and Cancer Council Victoria. The MCCS was further supported by Australian National Health and Medical Research Council (NHMRC) grants 209057 and 396414 and by infrastructure provided by Cancer Council Victoria. This project was specifically funded by the National Health and Medical Research Council project grant 623208 (to D.R. English and D.W. Eyles).