Circulating 25-Hydroxyvitamin D Concentration and Risk of Breast, Prostate, and Colorectal Cancers: The Melbourne Collaborative Cohort Study
Alicia K Heath, Allison M Hodge, Peter R Ebeling, Darryl W Eyles, David Kvaskoff, Daniel D Buchanan, Graham G Giles, Elizabeth J Williamson, Dallas R English
Cancer Epidemiology Biomarkers & Prevention | AMER ASSOC CANCER RESEARCH | Published : 2019
BACKGROUND: The role of vitamin D in cancer risk remains controversial, and limited data exist on associations between vitamin D and subtypes of specific cancers. We investigated associations between circulating 25-hydroxyvitamin D (25(OH)D) and risk of colorectal, breast, and prostate cancers, including subtypes. METHODS: A case-cohort study within the Melbourne Collaborative Cohort Study included 547 colorectal, 634 breast, and 824 prostate cancers, and a sex-stratified random sample of participants (n = 2,996). Concentration of 25(OH)D in baseline-dried blood spots was measured using LC-MS/MS. Cox regression yielded adjusted HRs and 95% confidence intervals (CI) for each cancer in relatio..View full abstract
Awarded by Australian National Health and Medical Research Council (NHMRC)
Awarded by National Health and Medical Research Council
MCCS cohort recruitment was funded by VicHealth and Cancer Council Victoria. The MCCS was further supported by Australian National Health and Medical Research Council (NHMRC) grants 209057 and 396414 and by infrastructure provided by Cancer Council Victoria. This project was specifically funded by the National Health and Medical Research Council project grant 623208 (to D.R. English and D.W. Eyles).