Journal article

Acute effects of active breaks during prolonged sitting on subcutaneous adipose tissue gene expression: an ancillary analysis of a randomised controlled trial

Megan S Grace, Melissa F Formosa, Kiymet Bozaoglu, Audrey Bergouignan, Marta Brozynska, Andrew L Carey, Camilla Bertuzzo Veiga, Parneet Sethi, Francis Dillon, David A Bertovic, Michael Inouye, Neville Owen, David W Dunstan, Bronwyn A Kingwell

SCIENTIFIC REPORTS | NATURE PUBLISHING GROUP | Published : 2019

Abstract

Active breaks in prolonged sitting has beneficial impacts on cardiometabolic risk biomarkers. The molecular mechanisms include regulation of skeletal muscle gene and protein expression controlling metabolic, inflammatory and cell development pathways. An active communication network exists between adipose and muscle tissue, but the effect of active breaks in prolonged sitting on adipose tissue have not been investigated. This study characterized the acute transcriptional events induced in adipose tissue by regular active breaks during prolonged sitting. We studied 8 overweight/obese adults participating in an acute randomized three-intervention crossover trial. Interventions were performed i..

View full abstract

Grants

Awarded by National Health and Medical Research Council (NHMRC) of Australia Project Grant [NHMRC]


Awarded by NHMRC Program Grant [NHMRC]


Awarded by NHMRC Centre of Research Excellence Grant [NHMRC]


Awarded by NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES


Funding Acknowledgements

This work was supported by a National Health and Medical Research Council (NHMRC) of Australia Project Grant [NHMRC #540107] and an NHMRC Program Grant [NHMRC #569940]. This work was also partially supported by an OIS grant from the Victorian State Government and a NHMRC Centre of Research Excellence Grant [NHMRC #1041056]. Professors Kingwell, Owen, Inouye and Dunstan are NHMRC Research Fellows.